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Julien Pytkowicz

Professeur des Universités Directeur du Département de Chimie

Directeur, Chargé (e) de cours

Département de Chimie

01 34 25 73 34
  • Adresse : Laboratoire BioCIS Site de Neuville 5 mail Gay Lussac Neuville sur Oise 95031 Cergy-pontoise Cedex
Domaines d'expertise

Research Interests:

  • Asymmetric Synthesis of Trifluoromethylated compounds (Amino-acids, Amino-alcohols, Diamines)
  • Fluorinated Peptides and Pseudopeptides
  • Physicochemical and Biological Properties of Fluorinated Peptides
  • 19F NMR based enzymatic functional assays

Discipline(s) enseignée(s)

Chimie Organique, Chimie Générale, Chimie Organométallique, Bases de Données

Activités / CV

Scientific Career

  • 2018 Professor CY University BioCIS laboratory (UMR 8076)
  • 2017 CNU Qualification (32nd section)
  • 2012 « Habilitation à Diriger des Recherches » (HDR Cergy Pontoise University)
  • 2004 Assistant professor (32nd section) SOSCO (U.M.R 8123) Cergy Pontoise University, Pr. Thierry Brigaud’s team.
  • 2003-2004 ATER in the Molecular Catalysis Laboratory (U.M.R 8182) Paris-Sud University, Pr. Henri Kagan’s supervision.
  • 2002-2003 Post-doctoral position, Montreal University (UdM) André Charrette’s Laboratory
  • 1999-2002 PhD in Organic Chemistry under supervision of D.R. Pierre Mangeney in the Organic Chemistry Laboratory(UMR 7611)

Scientific Production

  • 29 Publications
  • 1 review
  • 9 proceedings
  • 21 oral communications
  • 4 invited conferences
  • 48 posters

Scientific Impact

  • 2021 INEX Emergence Program "FSIPRO"
  • 2018 ANR « F-LAIR » program (contributor)
  • 2017 ANR « CH2-Probe » program (contributor)
  • 2016 funding of UCP foundation « FOLDAFLU » project
  • 2016 Co-organization of the GIS Fluor thematic day « Fluor et Biomolécules : de l’acide aminé aux protéines »
  • 2014 Co-organization of the “Colloque Francophone de Chimie du Fluor CFCF”
  • 2009 P.E.S Grant
  • 2009 ANR JCJC« CF3-GPE » (contributor)
  • Since 2008 Member of the G.I.S. « Fluor » (CNRS) and member of GFPP (Groupe Français des Peptides et des Protéines)

Student’s Supervision

  • 5 ATER/Post-doct (co-supervision) ;
  • 5 PhD : 3 as co-director (50%), 2 en tant que co-supervisor
  • 12 Master students 2

Research Topics

  • Fluorinated Peptides: Synthesis and biological evaluation of several trifluoromethylated GPE analogs (ANR JCJC 2009, CF3-GPE, PI: G. Chaume). Introduction of trifluoromethylated amino acids in peptides: impact on hydrophobicity and proteolytic resistance. Trifluoromethylated peptides as NMR Probes (ANR CH2-Probe, ANR F-LAIR).
  • Enantiopure Fluorinated Synthons: Synthesis of trifluoromethylated enantiopur Amino Alcohols, Amino Acids and Diamines: application to the synthesis of trifluoromethylated polyureas Foldamers.
  • Assymetric Synthesis: Use of Fox (fluorinated oxazolidine) Chiral Auxiliary in diastereoselective transformation of amide enolates (alkylation, oxydation, fluoration)

Corps

Professeur des Universités